Notch signaling and taxis mechanisms regulate early stage angiogenesis: A mathematical and computational model.

During angiogenesis, new blood vessels sprout and grow from existing ones. This process plays a crucial role in organ development and repair, in wound healing and in numerous pathological processes such as cancer progression or diabetes. Here, we present a mathematical model of early stage angiogene...

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Bibliographic Details
Main Authors: Rocío Vega, Manuel Carretero, Rui D M Travasso, Luis L Bonilla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS Computational Biology
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1006919/2/pcbi.1006919.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210221%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210221T071554Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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