Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)<sub>2</sub>, in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2)

Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)<sub>2</sub>, in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2)

Overexpression of breast cancer resistance transporter (BCRP/ABCG2) in cancers has been explained for the failure of chemotherapy in clinic. Inhibition of the transport activity of BCRP during chemotherapy should reverse multidrug resistance. In this study, a triazole-bridged flavonoid dimer <b&g...

Full description

Bibliographic Details
Main Authors: Tsz Cheung Chong, Iris L. K. Wong, Jiahua Cui, Man Chun Law, Xuezhen Zhu, Xuesen Hu, Jason W. Y. Kan, Clare S. W. Yan, Tak Hang Chan, Larry M. C. Chow
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
multidrug resistance
breast cancer resistance protein
BCRP
ABCG2
flavonoid dimers
Online Access:https://www.mdpi.com/1422-0067/23/21/13261

Internet

https://www.mdpi.com/1422-0067/23/21/13261

Similar Items