Establishment and Thorough Characterization of Xenograft (PDX) Models Derived from Patients with Pancreatic Cancer for Molecular Analyses and Chemosensitivity Testing

Establishment and Thorough Characterization of Xenograft (PDX) Models Derived from Patients with Pancreatic Cancer for Molecular Analyses and Chemosensitivity Testing

Patient-derived xenograft (PDX) tumor models are essential for identifying new biomarkers, signaling pathways and novel targets, to better define key factors of therapy response and resistance mechanisms. Therefore, this study aimed at establishing pancreas carcinoma (PC) PDX models with thorough mo...

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Bibliographic Details
Main Authors: Diana Behrens, Ulrike Pfohl, Theresia Conrad, Michael Becker, Bernadette Brzezicha, Britta Büttner, Silvia Wagner, Cora Hallas, Rita Lawlor, Vladimir Khazak, Michael Linnebacher, Thomas Wartmann, Iduna Fichtner, Jens Hoffmann, Mathias Dahlmann, Wolfgang Walther
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cancers
Subjects:
pancreas carcinoma
PDX models
in vivo chemosensitivity testing
molecular profiling
Online Access:https://www.mdpi.com/2072-6694/15/24/5753

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https://www.mdpi.com/2072-6694/15/24/5753

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