Cell-to-cell transmitted alpha-synuclein recapitulates experimental Parkinson’s disease

Cell-to-cell transmitted alpha-synuclein recapitulates experimental Parkinson’s disease

Abstract Parkinson’s disease is characterized by a progressive accumulation of alpha-Synuclein (αSyn) neuronal inclusions called Lewy bodies in the nervous system. Lewy bodies can arise from the cell-to-cell propagation of αSyn, which can occur via sequential steps of secretion and uptake. Here, by...

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Bibliographic Details
Main Authors: Natalia Cecilia Prymaczok, Pablo Nicolas De Francesco, Samanta Mazzetti, Marie Humbert-Claude, Liliane Tenenbaum, Graziella Cappelletti, Eliezer Masliah, Mario Perello, Roland Riek, Juan Atilio Gerez
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00618-6

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https://doi.org/10.1038/s41531-023-00618-6

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