Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during <named-content content-type="genus-species">Clostridium difficile</named-content> Infections

Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during <named-content content-type="genus-species">Clostridium difficile</named-content> Infections

ABSTRACT Clostridium difficile is a leading cause of antibiotic-associated diarrhea, a significant animal pathogen, and a worldwide public health burden. Most disease-causing strains secrete two exotoxins, TcdA and TcdB, which are considered to be the primary virulence factors. Understanding the rol...

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Main Authors: Glen P. Carter, Anjana Chakravorty, Tu Anh Pham Nguyen, Steven Mileto, Fernanda Schreiber, Lucy Li, Pauline Howarth, Simon Clare, Bliss Cunningham, Susan P. Sambol, Adam Cheknis, Iris Figueroa, Stuart Johnson, Dale Gerding, Julian I. Rood, Gordon Dougan, Trevor D. Lawley, Dena Lyras
Format: Article
Language:English
Published: American Society for Microbiology 2015-07-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00551-15

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https://journals.asm.org/doi/10.1128/mBio.00551-15

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