Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

SUMMARY SHP-2 (encoded by PTPN11) is a ubiquitously expressed protein tyrosine phosphatase required for signal transduction by multiple different cell surface receptors. Humans with germline SHP-2 mutations develop Noonan syndrome or LEOPARD syndrome, which are characterized by cardiovascular, neuro...

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Bibliographic Details
Main Authors: Timothy J. Bauler, Nobuhiro Kamiya, Philip E. Lapinski, Eric Langewisch, Yuji Mishina, John E. Wilkinson, Gen-Sheng Feng, Philip D. King
Format: Article
Language:English
Published: The Company of Biologists 2011-03-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/4/2/228

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http://dmm.biologists.org/content/4/2/228

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