Macrophage-targeted anti-CCL2 immunotherapy enhances tumor sensitivity to 5-fluorouracil in a Balb/c-CT26 murine colon carcinoma model measured using diffuse reflectance spectroscopy

Macrophage-targeted anti-CCL2 immunotherapy enhances tumor sensitivity to 5-fluorouracil in a Balb/c-CT26 murine colon carcinoma model measured using diffuse reflectance spectroscopy

Abstract Background Immunotherapy in colorectal cancer (CRC) regulates specific immune checkpoints and, when used in combination with chemotherapy, can improve patient prognosis. One specific immune checkpoint is the recruitment of circulating monocytes that differentiate into tumor-associated macro...

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Bibliographic Details
Main Authors: Shelby N. Bess, Gage J. Greening, Narasimhan Rajaram, Timothy J. Muldoon
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Immunology
Subjects:
Colorectal cancer
Tumor-associated macrophages
Diffuse reflectance spectroscopy
Immunomodulation
Online Access:https://doi.org/10.1186/s12865-022-00493-5

Internet

https://doi.org/10.1186/s12865-022-00493-5

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