Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis

Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis

Hypoxic environments at high altitudes influence the long-term non-altitude health of residents, by inducing changes in metabolism and the mitochondria, severe lung injury, and endangering life. This study was aimed to determine whether meldonium can ameliorate hypoxia-induced lung injury and invest...

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Bibliographic Details
Main Authors: Daohui Wang, Fengying Liu, Weijie Yang, Yangyang Sun, Xiaoning Wang, Xin Sui, Jun Yang, Qian Wang, Wenhao Song, Minmin Zhang, Zhenyu Xiao, Tian Wang, Yongan Wang, Yuan Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
PFKP
lung injury
high altitude
hypoxia
oxidative stress
mitochondrion
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.863451/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.863451/full

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