SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19

SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19

Background: Toll-like receptors (TLRs) play a pivotal role in the immunologic response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Exaggerated inflammatory response of innate immune cells, however, may drive morbidity and death in Coronavirus disease 19 (COVID-19). Obj...

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Bibliographic Details
Main Authors: Sabina Sahanic, Richard Hilbe, Christina Dünser, Piotr Tymoszuk, Judith Löffler-Ragg, Dietmar Rieder, Zlatko Trajanoski, Anne Krogsdam, Egon Demetz, Maria Yurchenko, Christine Fischer, Michael Schirmer, Markus Theurl, Daniela Lener, Jakob Hirsch, Johannes Holfeld, Can Gollmann-Tepeköylü, Carl P. Zinner, Alexandar Tzankov, Shen-Ying Zhang, Jean-Laurent Casanova, Wilfried Posch, Doris Wilflingseder, Guenter Weiss, Ivan Tancevski
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Heliyon
Subjects:
SARS-CoV-2
Macrophages
Innate immunity
Toll-like receptors
COVID-19
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023091016

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http://www.sciencedirect.com/science/article/pii/S2405844023091016

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