The A226D Mutation of OmpC Leads to Increased Susceptibility to β-Lactam Antibiotics in <i>Escherichia coli</i>

The A226D Mutation of OmpC Leads to Increased Susceptibility to β-Lactam Antibiotics in <i>Escherichia coli</i>

Bacterial resistance to antibiotics can lead to long-lasting, hard-to-cure infections that pose significant threats to human health. One key mechanism of antimicrobial resistance (AMR) is to reduce the antibiotic permeation of cellular membranes. For instance, the lack of outer membrane porins (OMPs...

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Bibliographic Details
Main Authors: Jiaming Zhu, Peng Guo, Yuting Zheng, Shiqing Xiang, Yang Zhao, Xinyu Liu, Chengzhang Fu, Youming Zhang, Hai Xu, Ling Li, Wenjia Wang, Mingyu Wang
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Biology
Subjects:
antimicrobial resistance
outer membrane porin
β-lactam
OmpC
molecular dynamics
Online Access:https://www.mdpi.com/2079-7737/13/8/600

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https://www.mdpi.com/2079-7737/13/8/600

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