Epigenetic drug screening identifies enzyme inhibitors A-196 and TMP-269 as novel regulators of sprouting angiogenesis

Epigenetic drug screening identifies enzyme inhibitors A-196 and TMP-269 as novel regulators of sprouting angiogenesis

Abstract Epigenetic therapy has gained interest in treating cardiovascular diseases, but preclinical studies often encounter challenges with cell-type-specific effects or batch-to-batch variation, which have limited identification of novel drug candidates targeting angiogenesis. To address these lim...

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Bibliographic Details
Main Authors: M. Beter, H. H. Pulkkinen, T. Örd, A. Sormunen, L. Kilpeläinen, J. E. Dunford, M. U. Kaikkonen, E. Aavik, N. Laham-Karam, U. Oppermann, J. P. Laakkonen, S. Ylä-Herttuala
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Angiogenesis
TeloHAEC fibrin bead assay
Epigenetic screening
A-196
TMP-269
Epigenetic therapy
Online Access:https://doi.org/10.1038/s41598-024-84603-w

Internet

https://doi.org/10.1038/s41598-024-84603-w

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