Effect of sirolimus on insulin dynamics in horses

Effect of sirolimus on insulin dynamics in horses

Abstract Background Sirolimus, a mechanistic target of rapamycin inhibitor, suppresses insulin production in other species and has therapeutic potential for hyperinsulinemia in horses. Hypothesis/Objective Determine the pharmacokinetics (PKs) of sirolimus and evaluate its effect on insulin dynamics...

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Bibliographic Details
Main Authors: Demia J. deTonnerre, Carlos E. Medina Torres, Darko Stefanovski, Mary A. Robinson, Kate L. Kemp, François‐René Bertin, Andrew W. vanEps
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Journal of Veterinary Internal Medicine
Subjects:
endocrinopathic laminitis
equine metabolic syndrome
hyperinsulinemia
hyperinsulinemia‐associated laminitis
insulin dysregulation
pituitary pars intermedia dysfunction
Online Access:https://doi.org/10.1111/jvim.16650

Internet

https://doi.org/10.1111/jvim.16650

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