SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart.

SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart.

A major component of the cardiac stress response is the simultaneous activation of several gene regulatory networks. Interestingly, the transcriptional regulator steroid receptor coactivator-2, SRC-2 is often decreased during cardiac failure in humans. We postulated that SRC-2 suppression plays a me...

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Bibliographic Details
Main Authors: Erin L Reineke, Brian York, Erin Stashi, Xian Chen, Anna Tsimelzon, Jianming Xu, Christopher B Newgard, George E Taffet, Heinrich Taegtmeyer, Mark L Entman, Bert W O'Malley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3534027?pdf=render

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http://europepmc.org/articles/PMC3534027?pdf=render

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