Polo-like kinase 1 promotes pulmonary hypertension

Polo-like kinase 1 promotes pulmonary hypertension

Abstract Background Pulmonary hypertension (PH) is a lethal vascular disease with limited therapeutic options. The mechanistic connections between alveolar hypoxia and PH are not well understood. The aim of this study was to investigate the role of mitotic regulator Polo-like kinase 1 (PLK1) in PH d...

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Bibliographic Details
Main Authors: Rongrong Chen, Hongfei Wang, Cuiting Zheng, Xiyu Zhang, Li Li, Shengwei Wang, Hongyu Chen, Jing Duan, Xian Zhou, Haiyong Peng, Jing Guo, Anchen Zhang, Feifei Li, Wang Wang, Yu Zhang, Jun Wang, Chen Wang, Yan Meng, Xinling Du, Hongbing Zhang
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Respiratory Research
Subjects:
Pulmonary hypertension
Hypoxia
Polo-like kinase 1
HIF1α
RELA/p65
Online Access:https://doi.org/10.1186/s12931-023-02498-z

Internet

https://doi.org/10.1186/s12931-023-02498-z

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