Promoter-enhancer looping and shadow enhancers of the mouse αA-crystallin locus

Gene regulation by enhancers is important for precise temporal and spatial gene expression. Enhancers can drive gene expression regardless of their location, orientation or distance from the promoter. Changes in chromatin conformation and chromatin looping occur to bring the promoter and enhancers i...

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Bibliographic Details
Main Authors: Rebecca S. McGreal-Estrada, Louise V. Wolf, Ales Cvekl
Format: Article
Language:English
Published: The Company of Biologists 2018-12-01
Series:Biology Open
Subjects:
Online Access:http://bio.biologists.org/content/7/12/bio036897