Somatic Mutational Landscape in Mexican Patients: <i>CDH1</i> Mutations and chr20q13.33 Amplifications Are Associated with Diffuse-Type Gastric Adenocarcinoma

Somatic Mutational Landscape in Mexican Patients: <i>CDH1</i> Mutations and chr20q13.33 Amplifications Are Associated with Diffuse-Type Gastric Adenocarcinoma

The Hispanic population, compared with other ethnic groups, presents a more aggressive gastric cancer phenotype with higher frequency of diffuse-type gastric adenocarcinoma (GA); this could be related to the mutational landscape of GA in these patients. Using whole-exome sequencing, we sought to pre...

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Bibliographic Details
Main Authors: Dennis Cerrato-Izaguirre, Yolanda I. Chirino, Diddier Prada, Ericka Marel Quezada-Maldonado, Luis A Herrera, Angélica Hernández-Guerrero, Juan Octavio Alonso-Larraga, Roberto Herrera-Goepfert, Luis F. Oñate-Ocaña, David Cantú-de-León, Abelardo Meneses-García, Patricia Basurto-Lozada, Carla Daniela Robles-Espinoza, Javier Camacho, Claudia M. García-Cuellar, Yesennia Sánchez-Pérez
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
gastric cancer
Hispanic ethnicity
cancer genomics
precision medicine
copy number variation
mutations
Online Access:https://www.mdpi.com/1422-0067/23/19/11116

Internet

https://www.mdpi.com/1422-0067/23/19/11116

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