Somatic Mutational Landscape in Mexican Patients: <i>CDH1</i> Mutations and chr20q13.33 Amplifications Are Associated with Diffuse-Type Gastric Adenocarcinoma

Somatic Mutational Landscape in Mexican Patients: <i>CDH1</i> Mutations and chr20q13.33 Amplifications Are Associated with Diffuse-Type Gastric Adenocarcinoma

The Hispanic population, compared with other ethnic groups, presents a more aggressive gastric cancer phenotype with higher frequency of diffuse-type gastric adenocarcinoma (GA); this could be related to the mutational landscape of GA in these patients. Using whole-exome sequencing, we sought to pre...

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Bibliographic Details
Main Authors: Dennis Cerrato-Izaguirre, Yolanda I. Chirino, Diddier Prada, Ericka Marel Quezada-Maldonado, Luis A Herrera, Angélica Hernández-Guerrero, Juan Octavio Alonso-Larraga, Roberto Herrera-Goepfert, Luis F. Oñate-Ocaña, David Cantú-de-León, Abelardo Meneses-García, Patricia Basurto-Lozada, Carla Daniela Robles-Espinoza, Javier Camacho, Claudia M. García-Cuellar, Yesennia Sánchez-Pérez
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
gastric cancer
Hispanic ethnicity
cancer genomics
precision medicine
copy number variation
mutations
Online Access:https://www.mdpi.com/1422-0067/23/19/11116
Description
Summary:The Hispanic population, compared with other ethnic groups, presents a more aggressive gastric cancer phenotype with higher frequency of diffuse-type gastric adenocarcinoma (GA); this could be related to the mutational landscape of GA in these patients. Using whole-exome sequencing, we sought to present the mutational landscape of GA from 50 Mexican patients who were treated at The Instituto Nacional de Cancerología from 2019 to 2020. We performed a comprehensive statistical analysis to explore the relationship of the genomic variants and clinical data such as tumor histology and presence of signet-ring cell, <i>H. pylori</i>, and EBV. We describe a potentially different mutational landscape between diffuse and intestinal GA in Mexican patients. Patients with intestinal-type GA tended to present a higher frequency of <i>NOTCH1</i> mutations, copy number gains in cytobands 13.14, 10q23.33, and 12q25.1, and copy number losses in cytobands 7p12, 14q24.2, and 11q13.1; whereas patients with diffuse-type GA tended to present a high frequency of <i>CDH1</i> mutations and CNV gains in cytobands 20q13.33 and 22q11.21. This is the first description of a mutational landscape of GA in Mexican patients to better understand tumorigenesis in Hispanic patients and lay the groundwork for discovering potential biomarkers and therapeutic targets.
ISSN:1661-6596
1422-0067

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