The ups and downs of mutation frequencies during aging can account for the Apert syndrome paternal age effect.
Apert syndrome is almost always caused by a spontaneous mutation of paternal origin in one of two nucleotides in the fibroblast growth factor receptor 2 gene (FGFR2). The incidence of this disease increases with the age of the father (paternal age effect), and this increase is greater than what woul...
| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | English |
| Publicado: |
Public Library of Science (PLoS)
2009-07-01
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| Colección: | PLoS Genetics |
| Acceso en línea: | http://europepmc.org/articles/PMC2700275?pdf=render |