A KO mouse model for the lncRNA Lhx1os produces motor neuron alterations and locomotor impairment

A KO mouse model for the lncRNA Lhx1os produces motor neuron alterations and locomotor impairment

Summary: Here, we describe a conserved motor neuron-specific long non-coding RNA, Lhx1os, whose knockout in mice produces motor impairment and postnatal reduction of mature motor neurons (MNs). The ER stress-response pathway result specifically altered with the downregulation of factors involved in...

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Bibliographic Details
Main Authors: Flaminia Pellegrini, Vittorio Padovano, Silvia Biscarini, Tiziana Santini, Adriano Setti, Silvia Giulia Galfrè, Valentina Silenzi, Erika Vitiello, Davide Mariani, Carmine Nicoletti, Giulia Torromino, Elvira De Leonibus, Julie Martone, Irene Bozzoni
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:iScience
Subjects:
Neurogenetics
Behavioral neuroscience
Molecular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222021642

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http://www.sciencedirect.com/science/article/pii/S2589004222021642

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