The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking

The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking

The correct establishment and maintenance of unidirectional Notch signaling are critical for the homeostasis of various stem cell lineages. However, the molecular mechanisms that prevent cell-autonomous ectopic Notch signaling activation and deleterious cell fate decisions remain unclear. Here we sh...

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Bibliographic Details
Main Authors: Bo Li, Chouin Wong, Shihong Max Gao, Rulan Zhang, Rongbo Sun, Yulong Li, Yan Song
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Series:eLife
Subjects:
retromer
progenitor dedifferentiation
neuroblast
notch trafficking
tumorigenesis
neural stem cell
Online Access:https://elifesciences.org/articles/38181

Internet

https://elifesciences.org/articles/38181

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