Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production

Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production

Dermal papilla cells (DPCs) play important roles in hair growth regulation. However, strategies to regrow hair are lacking. Here, global proteomic profiling identified the tetrathiomolybdate (TM)-mediated inactivation of copper (Cu) depletion-dependent mitochondrial cytochrome c oxidase (COX) as the...

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Bibliographic Details
Main Authors: Fan Li, Hongli Liu, Xiaojing Wu, Zhicheng Song, Haojia Tang, Maohua Gong, Lei Liu, Fuchang Li
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
dermal papilla cells
copper
ROS
hair follicle
ALP
Online Access:https://www.mdpi.com/1422-0067/24/4/3123

Internet

https://www.mdpi.com/1422-0067/24/4/3123

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