A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes

A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes

The ubiquitin-editing protein A20 (TNFAIP3) is a known key player in the regulation of immune responses in many organs. Genome-wide associated studies (GWASs) have linked A20 with a number of inflammatory and autoimmune disorders, including psoriasis. Here, we identified a previously unrecognized ro...

Full description

Bibliographic Details
Main Authors: Maria Feoktistova, Roman Makarov, Sihem Brenji, Anne T. Schneider, Guido J. Hooiveld, Tom Luedde, Martin Leverkus, Amir S. Yazdi, Diana Panayotova-Dimitrova
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
cell death
keratinocytes
a20
nf-κb signaling
ripoptosome
Online Access:https://www.mdpi.com/2073-4409/9/2/351

Internet

https://www.mdpi.com/2073-4409/9/2/351

Similar Items