Discovery of novel isonipecotic acid-based heteroaryl amino acid derivatives as potential anticonvulsant agents: Design, synthesis, in-silico ADME study, and molecular docking studies

Discovery of novel isonipecotic acid-based heteroaryl amino acid derivatives as potential anticonvulsant agents: Design, synthesis, in-silico ADME study, and molecular docking studies

Background: Epilepsy is a neurological disorder characterized by anomalous brain activity, convulsions, and odd behavior. Several substituted-(naphthalen-2-yl)-3-(1H-indol-3-yl) allyl)-1,4-dihydropyridine-4-carboxylic acid derivatives (5a-j) were intended to be produced in the current research effor...

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Bibliographic Details
Main Authors: Mohammad M Ahmad, Naseem Akhtar, Shamshir Khan, Mohd Rashid, Md Tanwir Athar, Zabih Ullah, Mohamad Taleuzzaman
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Journal of Pharmacy and Bioallied Sciences
Subjects:
anticonvulsant activity
gaba-a indole
in-silico
molecular docking
pyridine
Online Access:http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2023;volume=15;issue=4;spage=205;epage=211;aulast=Ahmad

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http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2023;volume=15;issue=4;spage=205;epage=211;aulast=Ahmad

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