Premorbid Alterations of Spontaneous Brain Activity in Elderly Patients With Early Post-operative Cognitive Dysfunction: A Pilot Resting-State Functional MRI Study
Background: Elderly patients with pre-existing cognitive impairment are susceptible to post-operative cognitive dysfunction (POCD). In this study, we investigated whether there is pre-existing local homogeneity and functional connectivity alteration in the brain before surgery for POCD patients as c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.01062/full |
| _version_ | 1811337153330806784 |
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| author | Xixue Zhang Xixue Zhang Hui Li Hui Li Yating Lv Yating Lv Zhenghong Zhu Xiaoyong Shen Qi Lu Wei Wang Zhaoxin Wang Zhaoxin Wang Zhaoshun Jiang Zhaoshun Jiang Lvjun Yang Lvjun Yang Guangwu Lin Weidong Gu Weidong Gu |
| author_facet | Xixue Zhang Xixue Zhang Hui Li Hui Li Yating Lv Yating Lv Zhenghong Zhu Xiaoyong Shen Qi Lu Wei Wang Zhaoxin Wang Zhaoxin Wang Zhaoshun Jiang Zhaoshun Jiang Lvjun Yang Lvjun Yang Guangwu Lin Weidong Gu Weidong Gu |
| author_sort | Xixue Zhang |
| collection | DOAJ |
| description | Background: Elderly patients with pre-existing cognitive impairment are susceptible to post-operative cognitive dysfunction (POCD). In this study, we investigated whether there is pre-existing local homogeneity and functional connectivity alteration in the brain before surgery for POCD patients as compared to that in non-POCD patients.Methods: Eighty elderly patients undergoing major thoracic or abdominal surgeries were recruited. Resting-state functional MRI was scanned at least 1 day before surgery. Neuropsychological tests (NPTs) were performed before surgery and at discharge, respectively. Pre-operative regional homogeneity (ReHo) and resting-state functional connectivity (RSFC) were compared between POCD patients and non-POCD patients, respectively. Partial correlation between NPTs and ReHo or RSFC was analyzed by adjusting for confounding factors.Results: Significant difference (P < 0.001, Gaussian Random Field (GRF) correction which is a multiple comparisons correction method at cluster level, cluster size > 49) in ReHo between POCD patients and non-POCD patients was detected in right hippocampus/parahippocampus. Pre-operative RSFC between right hippocampus/parahippocampus and right middle/inferior temporal gyrus increased in POCD patients (P < 0.001, GRF correction for multiple comparisons) when compared with that in non-POCD patients.RSFC significantly correlated with composite Z-score (r = 0.46, 95% CI [0.234, 0.767], P = 0.002) or Digit Symbol Substitution Test Z-scores (r = 0.31, 95% CI [0.068, 0.643], P = 0.046) after adjusting for confounding factors.Conclusions: The results suggest that premorbid alterations of spontaneous brain activity might exist in elderly patients who develop early POCD. The neural mechanism by which patients with pre-operative abnormal spontaneous activity are susceptible to POCD requires further study. |
| first_indexed | 2024-04-13T17:50:45Z |
| format | Article |
| id | doaj.art-b496fb3327714e5fac30235f2fb75e28 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T17:50:45Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-b496fb3327714e5fac30235f2fb75e282022-12-22T02:36:44ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-10-011010.3389/fneur.2019.01062464355Premorbid Alterations of Spontaneous Brain Activity in Elderly Patients With Early Post-operative Cognitive Dysfunction: A Pilot Resting-State Functional MRI StudyXixue Zhang0Xixue Zhang1Hui Li2Hui Li3Yating Lv4Yating Lv5Zhenghong Zhu6Xiaoyong Shen7Qi Lu8Wei Wang9Zhaoxin Wang10Zhaoxin Wang11Zhaoshun Jiang12Zhaoshun Jiang13Lvjun Yang14Lvjun Yang15Guangwu Lin16Weidong Gu17Weidong Gu18Department of Anesthesiology, Huadong Hospital, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, ChinaDepartment of Anesthesiology, Huadong Hospital, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, ChinaInstitutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, ChinaZhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, ChinaDepartment of Thoracic Surgery, Huadong Hospital, Fudan University, Shanghai, ChinaDepartment of Thoracic Surgery, Huadong Hospital, Fudan University, Shanghai, ChinaDepartment of General Surgery, Huadong Hospital, Fudan University, Shanghai, ChinaDepartment of General Surgery, Huadong Hospital, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai, ChinaInstitute of Cognitive Neuroscience, East China Normal University, Shanghai, ChinaDepartment of Anesthesiology, Huadong Hospital, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, ChinaDepartment of Anesthesiology, Huadong Hospital, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, ChinaDepartment of Radiology, Huadong Hospital, Fudan University, Shanghai, ChinaDepartment of Anesthesiology, Huadong Hospital, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, ChinaBackground: Elderly patients with pre-existing cognitive impairment are susceptible to post-operative cognitive dysfunction (POCD). In this study, we investigated whether there is pre-existing local homogeneity and functional connectivity alteration in the brain before surgery for POCD patients as compared to that in non-POCD patients.Methods: Eighty elderly patients undergoing major thoracic or abdominal surgeries were recruited. Resting-state functional MRI was scanned at least 1 day before surgery. Neuropsychological tests (NPTs) were performed before surgery and at discharge, respectively. Pre-operative regional homogeneity (ReHo) and resting-state functional connectivity (RSFC) were compared between POCD patients and non-POCD patients, respectively. Partial correlation between NPTs and ReHo or RSFC was analyzed by adjusting for confounding factors.Results: Significant difference (P < 0.001, Gaussian Random Field (GRF) correction which is a multiple comparisons correction method at cluster level, cluster size > 49) in ReHo between POCD patients and non-POCD patients was detected in right hippocampus/parahippocampus. Pre-operative RSFC between right hippocampus/parahippocampus and right middle/inferior temporal gyrus increased in POCD patients (P < 0.001, GRF correction for multiple comparisons) when compared with that in non-POCD patients.RSFC significantly correlated with composite Z-score (r = 0.46, 95% CI [0.234, 0.767], P = 0.002) or Digit Symbol Substitution Test Z-scores (r = 0.31, 95% CI [0.068, 0.643], P = 0.046) after adjusting for confounding factors.Conclusions: The results suggest that premorbid alterations of spontaneous brain activity might exist in elderly patients who develop early POCD. The neural mechanism by which patients with pre-operative abnormal spontaneous activity are susceptible to POCD requires further study.https://www.frontiersin.org/article/10.3389/fneur.2019.01062/fullresting-state fMRIpre-operative changes in braincognitive declineearly post-operative periodfunctional connectivityregional homogeneity |
| spellingShingle | Xixue Zhang Xixue Zhang Hui Li Hui Li Yating Lv Yating Lv Zhenghong Zhu Xiaoyong Shen Qi Lu Wei Wang Zhaoxin Wang Zhaoxin Wang Zhaoshun Jiang Zhaoshun Jiang Lvjun Yang Lvjun Yang Guangwu Lin Weidong Gu Weidong Gu Premorbid Alterations of Spontaneous Brain Activity in Elderly Patients With Early Post-operative Cognitive Dysfunction: A Pilot Resting-State Functional MRI Study Frontiers in Neurology resting-state fMRI pre-operative changes in brain cognitive decline early post-operative period functional connectivity regional homogeneity |
| title | Premorbid Alterations of Spontaneous Brain Activity in Elderly Patients With Early Post-operative Cognitive Dysfunction: A Pilot Resting-State Functional MRI Study |
| title_full | Premorbid Alterations of Spontaneous Brain Activity in Elderly Patients With Early Post-operative Cognitive Dysfunction: A Pilot Resting-State Functional MRI Study |
| title_fullStr | Premorbid Alterations of Spontaneous Brain Activity in Elderly Patients With Early Post-operative Cognitive Dysfunction: A Pilot Resting-State Functional MRI Study |
| title_full_unstemmed | Premorbid Alterations of Spontaneous Brain Activity in Elderly Patients With Early Post-operative Cognitive Dysfunction: A Pilot Resting-State Functional MRI Study |
| title_short | Premorbid Alterations of Spontaneous Brain Activity in Elderly Patients With Early Post-operative Cognitive Dysfunction: A Pilot Resting-State Functional MRI Study |
| title_sort | premorbid alterations of spontaneous brain activity in elderly patients with early post operative cognitive dysfunction a pilot resting state functional mri study |
| topic | resting-state fMRI pre-operative changes in brain cognitive decline early post-operative period functional connectivity regional homogeneity |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.01062/full |
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