Wharton's Jelly mesenchymal stromal cell‐derived extracellular vesicles promote nucleus pulposus cell anabolism in an in vitro 3D alginate‐bead culture model

Wharton's Jelly mesenchymal stromal cell‐derived extracellular vesicles promote nucleus pulposus cell anabolism in an in vitro 3D alginate‐bead culture model

Abstract Background Intradiscal transplantation of mesenchymal stromal cells (MSCs) has emerged as a promising therapy for intervertebral disc degeneration (IDD). However, the hostile microenvironment of the intervertebral disc (IVD) may compromise the survival of implanted cells. Interestingly, stu...

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Bibliographic Details
Main Authors: Veronica Tilotta, Gianluca Vadalà, Luca Ambrosio, Giuseppina Di Giacomo, Claudia Cicione, Fabrizio Russo, Adas Darinskas, Rocco Papalia, Vincenzo Denaro
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:JOR Spine
Subjects:
exosome
extracellular vesicles
intervertebral disc
intervertebral disc degeneration
intervertebral disc regeneration
low back pain
Online Access:https://doi.org/10.1002/jsp2.1274

Internet

https://doi.org/10.1002/jsp2.1274

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