Translational Control of the SigR-Directed Oxidative Stress Response in <italic toggle="yes">Streptomyces</italic> via IF3-Mediated Repression of a Noncanonical GTC Start Codon

Translational Control of the SigR-Directed Oxidative Stress Response in <italic toggle="yes">Streptomyces</italic> via IF3-Mediated Repression of a Noncanonical GTC Start Codon

ABSTRACT The major oxidative stress response in Streptomyces is controlled by the sigma factor SigR and its cognate antisigma factor RsrA, and SigR activity is tightly controlled through multiple mechanisms at both the transcriptional and posttranslational levels. Here we show that sigR has a highly...

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Bibliographic Details
Main Authors: Morgan A. Feeney, Govind Chandra, Kim C. Findlay, Mark S. B. Paget, Mark J. Buttner
Format: Article
Language:English
Published: American Society for Microbiology 2017-07-01
Series:mBio
Subjects:
IF3
noncanonical start codon
oxidative stress
sigma factors
translation initiation
Online Access:https://journals.asm.org/doi/10.1128/mBio.00815-17

Internet

https://journals.asm.org/doi/10.1128/mBio.00815-17

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