A multi-omics study to characterize the transdifferentiation of human dermal fibroblasts to osteoblast-like cells

A multi-omics study to characterize the transdifferentiation of human dermal fibroblasts to osteoblast-like cells

Background: Various skeletal disorders display defects in osteoblast development and function. An in vitro model can help to understand underlying disease mechanisms. Currently, access to appropriate starting material for in vitro osteoblastic studies is limited. Native osteoblasts and their progeni...

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Bibliographic Details
Main Authors: Sandra Pihlström, Kirsi Määttä, Tiina Öhman, Riikka E. Mäkitie, Mira Aronen, Markku Varjosalo, Outi Mäkitie, Minna Pekkinen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
in vitro method
fibroblasts
transdifferentiation
osteoblast-like cells
osteoblastic differentiation treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1032026/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.1032026/full

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