Mice lacking DKK1 in T cells exhibit high bone mass and are protected from estrogen-deficiency-induced bone loss

Mice lacking DKK1 in T cells exhibit high bone mass and are protected from estrogen-deficiency-induced bone loss

Summary: The Wnt inhibitor Dickkopf-1 (DKK1) is a negative regulator of bone formation and bone mass and is dysregulated in various bone diseases. How DKK1 contributes to postmenopausal osteoporosis, however, remains poorly understood. Here, we show that mice lacking DKK1 in T cells are protected fr...

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Bibliographic Details
Main Authors: Juliane Lehmann, Sylvia Thiele, Ulrike Baschant, Tilman D. Rachner, Christof Niehrs, Lorenz C. Hofbauer, Martina Rauner
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:iScience
Subjects:
Molecular Physiology
Immunology
Cell Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221001929

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221001929

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