Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case.

Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case.

Impaired nitric oxide (NO˙)-cyclic guanosine 3', 5'-monophosphate (cGMP) signaling has been observed in many cardiovascular disorders, including heart failure and pulmonary arterial hypertension. There are several enzymatic determinants of cGMP levels in this pathway, including soluble gua...

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Bibliographic Details
Main Authors: Farshid S Garmaroudi, Diane E Handy, Yang-Yu Liu, Joseph Loscalzo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-03-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4795786?pdf=render

Internet

http://europepmc.org/articles/PMC4795786?pdf=render

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