High-content CRISPR screening in tumor immunology

High-content CRISPR screening in tumor immunology

CRISPR screening is a powerful tool that links specific genetic alterations to corresponding phenotypes, thus allowing for high-throughput identification of novel gene functions. Pooled CRISPR screens have enabled discovery of innate and adaptive immune response regulators in the setting of viral in...

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Bibliographic Details
Main Authors: Erin A. Holcomb, Ashley N. Pearson, Kassidy M. Jungles, Akshay Tate, Jadyn James, Long Jiang, Amanda K. Huber, Michael D. Green
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
CRISPR screen
tumor immunology
cancer immunotherapy
transcriptomic readout
epigenetic readout
proteomic readout
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1041451/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1041451/full

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