Mechanistic Studies of the Negative Epistatic Malaria-protective Interaction Between Sickle Cell Trait and α+thalassemia

Mechanistic Studies of the Negative Epistatic Malaria-protective Interaction Between Sickle Cell Trait and α+thalassemia

Background: Individually, the red blood cell (RBC) polymorphisms sickle cell trait (HbAS) and α+thalassemia protect against severe Plasmodium falciparum malaria. It has been shown through epidemiological studies that the co-inheritance of both conditions results in a loss of the protection afforded...

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Bibliographic Details
Main Authors: D. Herbert Opi, Lucy B. Ochola, Metrine Tendwa, Bethsheba R. Siddondo, Harold Ocholla, Harry Fanjo, Ashfaq Ghumra, David J.P. Ferguson, J. Alexandra Rowe, Thomas N. Williams
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:EBioMedicine
Subjects:
Malaria
Sickle cell trait
α+thalassemia
Epistasis
Cytoadhesion
PfEMP1
Red blood cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396414000085

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http://www.sciencedirect.com/science/article/pii/S2352396414000085

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