Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
<p>Abstract</p> <p>Background</p> <p><it>Plasmodium falciparum </it>readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competiti...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2010-03-01
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Series: | Malaria Journal |
Online Access: | http://www.malariajournal.com/content/9/1/65 |