Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation

Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation

Abstract Background Central sensitization is considered a critical pathogenic mechanism of chronic migraine (CM). Activation of microglia in the trigeminal nucleus caudalis (TNC) contributes to this progression. Microglial glucagon-like peptide-1 receptor (GLP-1R) activation can alleviate pain; howe...

Full description

Bibliographic Details
Main Authors: Feng Jing, Qian Zou, Yangyang Wang, Zhiyou Cai, Yong Tang
Format: Article
Language:English
Published: BMC 2021-07-01
Series:The Journal of Headache and Pain
Subjects:
GLP-1 receptor
Chronic migraine
Microglia
Central sensitization
Trigeminal nucleus caudalis
Nitroglycerin
Online Access:https://doi.org/10.1186/s10194-021-01302-x

Internet

https://doi.org/10.1186/s10194-021-01302-x

Similar Items