Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation

Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation

Abstract Background Central sensitization is considered a critical pathogenic mechanism of chronic migraine (CM). Activation of microglia in the trigeminal nucleus caudalis (TNC) contributes to this progression. Microglial glucagon-like peptide-1 receptor (GLP-1R) activation can alleviate pain; howe...

Full description

Bibliographic Details
Main Authors:	Feng Jing, Qian Zou, Yangyang Wang, Zhiyou Cai, Yong Tang
Format:	Article
Language:	English
Published:	BMC 2021-07-01
Series:	The Journal of Headache and Pain
Subjects:	GLP-1 receptor Chronic migraine Microglia Central sensitization Trigeminal nucleus caudalis Nitroglycerin
Online Access:	https://doi.org/10.1186/s10194-021-01302-x

Similar Items

P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine
by: Feng Jing, et al.
Published: (2019-11-01)

A study on the correlation of the asymmetric regulation between the periaqueductal gray and the bilateral trigeminal nucleus caudalis in migraine male rats
by: Zhijian Cao, et al.
Published: (2023-03-01)

AMPK activation attenuates central sensitization in a recurrent nitroglycerin-induced chronic migraine mouse model by promoting microglial M2-type polarization
by: Guangshuang Lu, et al.
Published: (2024-03-01)

The Up-regulation of TNF-α Maintains Trigeminal Neuralgia by Modulating MAPKs Phosphorylation and BKCa Channels in Trigeminal Nucleus Caudalis
by: Zhan-ying Lu, et al.
Published: (2021-11-01)

Transcriptomic Analysis of Trigeminal Ganglion and Spinal Trigeminal Nucleus Caudalis in Mice with Inflammatory Temporomandibular Joint Pain
by: Dong T, et al.
Published: (2022-05-01)

Differences in Neuropathology between Nitroglycerin-Induced Mouse Models of Episodic and Chronic Migraine
by: Songyi Park, et al.
Published: (2024-03-01)

A Pre-Existing Myogenic Temporomandibular Disorder Increases Trigeminal Calcitonin Gene-Related Peptide and Enhances Nitroglycerin-Induced Hypersensitivity in Mice
by: Hui Shu, et al.
Published: (2020-06-01)

The study of the Mongolian traditional medicine Khurtsiin deed-6 analgesic and anti-inflammatory effect by inhibiting glial cell activation in nitroglycerin-induced migraine in rats
by: Jargalsaikhan Gombodorj, et al.
Published: (2023-02-01)

Calcitonin gene-related peptide facilitates sensitization of the vestibular nucleus in a rat model of chronic migraine
by: Yun Zhang, et al.
Published: (2020-06-01)

The ditans, a new class for acute migraine: Minireview
by: Jamir Pitton Rissardo, et al.
Published: (2020-01-01)

NMDAR and JNK Activation in the Spinal Trigeminal Nucleus Caudalis Contributes to Masseter Hyperalgesia Induced by Stress
by: Wenqing Lin, et al.
Published: (2019-11-01)

An experimental research on the expression of c-Fos protein in trigeminal nucleus caudalis of migraine rat model induced by nitroglycerin after the intervention of Yangxueqingnao granules
by: Xiao-feng LEI, et al.
Published: (2014-08-01)

Sex Differences in Estradiol Secretion by Trigeminal Brainstem Neurons
by: David A. Bereiter, et al.
Published: (2019-02-01)

Potential mechanisms for osteopathic manipulative treatment to alleviate migraine-like pain in female rats
by: Katherine Byrd, et al.
Published: (2024-02-01)

Nitroglycerin as a model of migraine: Clinical and preclinical review
by: Paula Sureda-Gibert, et al.
Published: (2022-08-01)

The effect of capsaicin on expression patterns of CGRP in trigeminal ganglion and trigeminal nucleus caudalis following experimental tooth movement in rats
by: Yang ZHOU, et al.

Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain
by: Pawan Bista, et al.
Published: (2019-08-01)

Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators
by: Ahmed I. Foudah, et al.
Published: (2022-11-01)

Microglia P2X4 receptor contributes to central sensitization following recurrent nitroglycerin stimulation
by: Ting Long, et al.
Published: (2018-08-01)

Alternative Splicing of Neuropeptide Prohormone and Receptor Genes Associated with Pain Sensitivity Was Detected with Zero-Inflated Models
by: Bruce R. Southey, et al.
Published: (2022-04-01)

Properties of neurons in the superficial laminae of trigeminal nucleus caudalis
by: Bruno Pradier, et al.
Published: (2019-06-01)

Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats
by: Elena Gerasimova, et al.
Published: (2022-05-01)

The plasma fibrinogen levels in the nitroglycerin-induced chronic migraine rat model and its association between migraine-associated vestibular dysfunction
by: Jilei Zhang, et al.
Published: (2023-03-01)

Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing
by: Rosaria Greco, et al.
Published: (2018-07-01)

Excitatory Effects of Calcitonin Gene-Related Peptide (CGRP) on Superficial Sp5C Neurons in Mouse Medullary Slices
by: Fang Zheng, et al.
Published: (2021-04-01)

SOMATOTOPY OF THE TRIGEMINAL COMPLEX: NERVE, GANGLION, NUCLEUS.
by: Alessio Lipari
Published: (2017-12-01)

PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic migraine
by: Lily Zhang, et al.
Published: (2023-06-01)

IL-17 crosses the blood–brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine
by: Hao Chen, et al.
Published: (2022-01-01)

Commentary: The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat
by: Marcelo Moraes Valença
Published: (2017-09-01)

Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain
by: Cindy Guerrero-Toro, et al.
Published: (2022-01-01)

FAAH inhibition as a preventive treatment for migraine: A pre-clinical study
by: Rosaria Greco, et al.
Published: (2020-02-01)

Inhibition of glutamatergic trigeminal nucleus caudalis- vestibular nucleus projection neurons attenuates vestibular dysfunction in the chronic-NTG model of migraine
by: Yun Zhang, et al.
Published: (2023-06-01)

Cerebral Blood Flow and Migraine
by: J Gordon Millichap
Published: (2008-08-01)

The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat
by: Gábor Nagy-Grócz, et al.
Published: (2017-06-01)

The mTOR inhibitor rapamycin suppresses trigeminal neuropathic pain and p-MKK4/p-p38 mitogen-activated protein kinase-mediated microglial activation in the trigeminal nucleus caudalis of mice with infraorbital nerve injury
by: Ji-Hee Yeo, et al.
Published: (2023-04-01)

Hydrogen Sulfide Mediating both Excitatory and Inhibitory Effects in a Rat Model of Meningeal Nociception and Headache Generation
by: Christiane Teicher, et al.
Published: (2017-07-01)

Neuronal Cell Types in the Spinal Trigeminal Nucleus of the Camel Brain
by: Qasim A. El-Dwairi, et al.
Published: (2023-02-01)

Corrigendum: The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat
by: Gábor Nagy-Grócz, et al.
Published: (2020-09-01)

Effects of Nitric Oxide on the Activity of P2X and TRPV1 Receptors in Rat Meningeal Afferents of the Trigeminal Nerve
by: Kseniia Koroleva, et al.
Published: (2023-04-01)

Pharmacological Characterization of Orofacial Nociception in Female Rats Following Nitroglycerin Administration
by: Robert M. Caudle, et al.
Published: (2020-12-01)