The ecology of antibiotic use in the ICU: homogeneous prescribing of cefepime but not tazocin selects for antibiotic resistant infection.

The ecology of antibiotic use in the ICU: homogeneous prescribing of cefepime but not tazocin selects for antibiotic resistant infection.

BACKGROUND: Antibiotic homogeneity is thought to drive resistance but in vivo data are lacking. In this study, we determined the impact of antibiotic homogeneity per se, and of cefepime versus antipseudomonal penicillin/β-lactamase inhibitor combinations (APP-β), on the likelihood of infection or co...

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Bibliographic Details
Main Authors: Andrew N Ginn, Agnieszka M Wiklendt, Heather F Gidding, Narelle George, James S O'Driscoll, Sally R Partridge, Brian I O'Toole, Rita A Perri, Joan Faoagali, John E Gallagher, Jeffrey Lipman, Jonathan R Iredell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3382621?pdf=render

Internet

http://europepmc.org/articles/PMC3382621?pdf=render

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