YB-1-based oncolytic virotherapy in combination with CD47 blockade enhances phagocytosis of pediatric sarcoma cells

YB-1-based oncolytic virotherapy in combination with CD47 blockade enhances phagocytosis of pediatric sarcoma cells

Oncolytic viruses (OVs) selectively replicate in tumor cells resulting in lysis, spreading of new infectious units and induction of antitumor immune responses through abrogating an immunosuppressive tumor microenvironment (TME). Due to their mode of action, OVs are ideal combination partners with ta...

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Bibliographic Details
Main Authors: Anna Josefine von Ofen, Uwe Thiel, Jennifer Eck, Hendrik Gassmann, Melanie Thiede, Julia Hauer, Per Sonne Holm, Sebastian J. Schober
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Oncology
Subjects:
pediatric sarcoma
oncolytic virotherapy
phagocytosis
cd47
don’t-eat-me-signal
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1304374/full

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https://www.frontiersin.org/articles/10.3389/fonc.2024.1304374/full

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