The Accurate Prediction of Antibody Deamidations by Combining High-Throughput Automated Peptide Mapping and Protein Language Model-Based Deep Learning

Therapeutic antibodies such as monoclonal antibodies (mAbs), bispecific and multispecific antibodies are pivotal in therapeutic protein development and have transformed disease treatments across various therapeutic areas. The integrity of therapeutic antibodies, however, is compromised by sequence l...

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Bibliographic Details
Main Authors: Ben Niu, Benjamin Lee, Lili Wang, Wen Chen, Jeffrey Johnson
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Antibodies
Subjects:
Online Access:https://www.mdpi.com/2073-4468/13/3/74