Role of amphipathic helix of a herpesviral protein in membrane deformation and T cell receptor downregulation.

Role of amphipathic helix of a herpesviral protein in membrane deformation and T cell receptor downregulation.

Lipid rafts are membrane microdomains that function as platforms for signal transduction and membrane trafficking. Tyrosine kinase interacting protein (Tip) of T lymphotropic Herpesvirus saimiri (HVS) is targeted to lipid rafts in T cells and downregulates TCR and CD4 surface expression. Here, we re...

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Bibliographic Details
Main Authors: Chan-Ki Min, Sun-Young Bang, Bon-A Cho, Yun-Hui Choi, Jae-Seong Yang, Sun-Hwa Lee, Seung-Yong Seong, Ki Woo Kim, Sanguk Kim, Jae Ung Jung, Myung-Sik Choi, Ik-Sang Kim, Nam-Hyuk Cho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2581436?pdf=render

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http://europepmc.org/articles/PMC2581436?pdf=render

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