Chloroquine Autophagic Inhibition Rebalances Th17/Treg-Mediated Immunity and Ameliorates Systemic Lupus Erythematosus

Chloroquine Autophagic Inhibition Rebalances Th17/Treg-Mediated Immunity and Ameliorates Systemic Lupus Erythematosus

Background: Imbalanced cellular immunity is critical to the pathogenesis of systemic lupus erythematosus (SLE). Recently, autophagy has emerged as a key homeostatic mechanism in T lymphocytes. This study was conducted to explore the impact of autophagy on the Th17/ regulatory T (Treg) immune imbalan...

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Bibliographic Details
Main Authors: Ning An, Yanwen Chen, Chao Wang, Chen Yang, Zhi-hong Wu, Jing Xue, Lin Ye, Shujun Wang, Hua-feng Liu, Qingjun Pan
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Autophagy
Hydroxychloroquine (chloroquine)
Systemic lupus erythematosus
Th17
Treg
Online Access:https://www.karger.com/Article/FullText/484955

Internet

https://www.karger.com/Article/FullText/484955

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