CHANGE OF PHENOTYPIC PROPERTIES OF ESCAPE MUTANTS AND READAPTANTS OF INFLUENZA VIRUS A (H1N1) PDM09 UNDER THE INFLUENCE OF SELECTED MUTATIONS IN THE MOLECULE OF HEMAGGLUTININ

CHANGE OF PHENOTYPIC PROPERTIES OF ESCAPE MUTANTS AND READAPTANTS OF INFLUENZA VIRUS A (H1N1) PDM09 UNDER THE INFLUENCE OF SELECTED MUTATIONS IN THE MOLECULE OF HEMAGGLUTININ

Introduction. After the emergence and spread of pandemic H1N1 viruses in 2009, antigenic epitopes recognized by neutralizing antibodies against the hemagglutinin of influenza A/Moscow/01/09(H1N1)pdm09 viruses were studied. Targets and goals. The purpose of the study was to obtain readapted variants...

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Bibliographic Details
Main Authors: T. A. Timofeeva, I. A. Rudneva, A. A. Shilov, M. A. Balanova, E. K. Artemov, A. A. Kushch, O. V. Masalova, R. R. Klimova, T. V. Grebennikova, N. V. Kaverin
Format: Article
Language:English
Published: Central Research Institute for Epidemiology 2019-04-01
Series:Вопросы вирусологии
Subjects:
influenza virus a (h1n1) pdm09
hemagglutinin h1
amino acid substitutions
antigen specificity
receptor-binding activity
virulence for mice
Online Access:https://virusjour.crie.ru/jour/article/viewFile/236/139

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https://virusjour.crie.ru/jour/article/viewFile/236/139

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