Obesity and metabolic dysfunction drive sex-associated differential disease profiles in hACE2-mice challenged with SARS-CoV-2

Obesity and metabolic dysfunction drive sex-associated differential disease profiles in hACE2-mice challenged with SARS-CoV-2

Summary: Severe outcomes from SARS-CoV-2 infection are highly associated with preexisting comorbid conditions like hypertension, diabetes, and obesity. We utilized the diet-induced obesity (DIO) model of metabolic dysfunction in K18-hACE2 transgenic mice to model obesity as a COVID-19 comorbidity. F...

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Bibliographic Details
Main Authors: Katherine S. Lee, Brynnan P. Russ, Ting Y. Wong, Alexander M. Horspool, Michael T. Winters, Mariette Barbier, Justin R. Bevere, Ivan Martinez, F. Heath Damron, Holly A. Cyphert
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Virology
Human metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222013104

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http://www.sciencedirect.com/science/article/pii/S2589004222013104

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