Probabilistic inference for nucleosome positioning with MNase-based or sonicated short-read data.

We describe a model-based method, PING, for predicting nucleosome positions in MNase-Seq and MNase- or sonicated-ChIP-Seq data. PING compares favorably to NPS and TemplateFilter in scalability, accuracy and robustness to low read density. To demonstrate that PING predictions from widely available so...

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Bibliographic Details
Main Authors: Xuekui Zhang, Gordon Robertson, Sangsoon Woo, Brad G Hoffman, Raphael Gottardo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3290535?pdf=render