Novel Method of Synthesis of 5''-Phosphate 2'-O-ribosyl-ribonucleosides and Their 3'-Phosphoramidites

Novel Method of Synthesis of 5''-Phosphate 2'-O-ribosyl-ribonucleosides and Their 3'-Phosphoramidites

Synthesis of 5''-phosphate 2'-O-ribosylribonucleosides [Nr(p)] of four common ribonucleosides, and 3'-phosphoramidites of 5''-phosphate 2'-O-ribosyladenosine and 2'-O-ribosylguanosine using the H-phosphonate chemistry is described. An additional ring protecte...

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Bibliographic Details
Main Authors: Marcin K. Chmielewski, Wojciech T. Markiewicz
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Molecules
Subjects:
2'-O-ribosylribonucleosides
ribosylation
methionine tRNA
initiator tRNA
H-phosphonate
phosphoramidite
nucleosides
nucleotides
Online Access:http://www.mdpi.com/1420-3049/18/12/14780

Internet

http://www.mdpi.com/1420-3049/18/12/14780

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