Alterations in Homologous Recombination-Related Genes and Distinct Platinum Response in Metastatic Triple-Negative Breast Cancers: A Subgroup Analysis of the ProfiLER-01 Trial

Alterations in Homologous Recombination-Related Genes and Distinct Platinum Response in Metastatic Triple-Negative Breast Cancers: A Subgroup Analysis of the ProfiLER-01 Trial

Background: a specific subset of metastatic triple-negative breast cancers (mTNBC) is characterized by homologous recombination deficiency (HRD), leading to enhanced sensitivity to platinum-based chemotherapy. Apart from mutations in <i>BRCA1/2</i> genes, the evaluation of other HRD-rela...

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Bibliographic Details
Main Authors: Elise Bonnet, Véronique Haddad, Stanislas Quesada, Kim-Arthur Baffert, Audrey Lardy-Cléaud, Isabelle Treilleux, Daniel Pissaloux, Valéry Attignon, Qing Wang, Adrien Buisson, Pierre-Etienne Heudel, Thomas Bachelot, Armelle Dufresne, Lauriane Eberst, Philippe Toussaint, Valérie Bonadona, Christine Lasset, Alain Viari, Emilie Sohier, Sandrine Paindavoine, Valérie Combaret, David Pérol, Isabelle Ray-Coquard, Jean-Yves Blay, Olivier Trédan
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Journal of Personalized Medicine
Subjects:
triple-negative breast cancer
TNBC
platinum-based chemotherapy
DNA repair
homologous recombination
HRR genes
Online Access:https://www.mdpi.com/2075-4426/12/10/1595

Internet

https://www.mdpi.com/2075-4426/12/10/1595

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