Ebola-GP DNA Prime rAd5-GP Boost: Influence of Prime Frequency and Prime/Boost Time Interval on the Immune Response in Non-human Primates

Ebola-GP DNA Prime rAd5-GP Boost: Influence of Prime Frequency and Prime/Boost Time Interval on the Immune Response in Non-human Primates

Heterologous prime-boost immunization regimens are a common strategy for many vaccines. DNA prime rAd5-GP boost immunization has been demonstrated to protect non-human primates against a lethal challenge of Ebola virus, a pathogen that causes fatal hemorrhagic disease in humans. This protection corr...

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Bibliographic Details
Main Authors: Hadar Marcus, Emily Thompson, Yan Zhou, Michael Bailey, Mitzi M. Donaldson, Daphne A. Stanley, Clement Asiedu, Kathryn E. Foulds, Mario Roederer, Juan I. Moliva, Nancy J. Sullivan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
vaccine
Ebola
prime
boost
CD8+
CD4+
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.627688/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.627688/full

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