NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport

Abstract Background Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized by Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) in CNS n...

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Main Authors: Sen Yang, Zhen-Xian Niou, Andrea Enriquez, Jacob LaMar, Jui-Yen Huang, Karen Ling, Paymaan Jafar-Nejad, Jonathan Gilley, Michael P. Coleman, Jason M. Tennessen, Vidhya Rangaraju, Hui-Chen Lu
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Molecular Neurodegeneration
Online Access:https://doi.org/10.1186/s13024-023-00690-9

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https://doi.org/10.1186/s13024-023-00690-9

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