Association between S. Typhi-specific memory CD4+ and CD8+ T responses in the terminal ileum mucosa and in peripheral blood elicited by the live oral typhoid vaccine Ty21a in humans

CD4+ and CD8+ T subsets are essential components of the adaptive immune system which act in concert at the site of infections to effectively protect against pathogens. Very limited data is available in humans regarding the relationship between CD4+ and CD8+ S. Typhi responsive cells in the terminal...

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Bibliographic Details
Main Authors: Jayaum S. Booth, Eric Goldberg, Seema A. Patil, Bruce D. Greenwald, Marcelo B. Sztein
Format: Article
Language:English
Published: Taylor & Francis Group 2019-06-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Online Access:http://dx.doi.org/10.1080/21645515.2018.1564570