Cellugyrin (synaptogyrin-2) dependent pathways are used by bacterial cytolethal distending toxin and SARS-CoV-2 virus to gain cell entry

Cellugyrin (synaptogyrin-2) dependent pathways are used by bacterial cytolethal distending toxin and SARS-CoV-2 virus to gain cell entry

Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is capable of intoxicating lymphocytes macrophages, mast cells and epithelial cells. Following Cdt binding to cholesterol, in the region of membrane lipid rafts, the CdtB and CdtC subunits are internalized and traffic to intrace...

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Bibliographic Details
Main Authors: Kathleen Boesze-Battaglia, Gary H. Cohen, Paul F. Bates, Lisa M. Walker, Ali Zekavat, Bruce J. Shenker
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
cellugyrin
synaptogyrin-2
cytolethal distending toxin
SARS-CoV-2
pathogen
cell entry
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1334224/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2024.1334224/full

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