COBRA methods and metabolic drug targets in cancer

COBRA methods and metabolic drug targets in cancer

The identification of therapeutic strategies exploiting the metabolic alterations of malignant cells is a relevant area in cancer research. Here, we discuss a novel computational method, based on the COBRA (COnstraint-Based Reconstruction and Analysis) framework for metabolic networks, to perform th...

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Bibliographic Details
Main Authors: Iñigo Apaolaza, Edurne San José-Eneriz, Xabier Agirre, Felipe Prósper, Francisco J. Planes
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Molecular & Cellular Oncology
Subjects:
cancer
constraint-based reconstruction and analysis
drug targets
essential genes
genetic minimal cut sets
metabolic networks
personalized medicine
synthetic lethality
Online Access:http://dx.doi.org/10.1080/23723556.2017.1389672

Internet

http://dx.doi.org/10.1080/23723556.2017.1389672

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