COBRA methods and metabolic drug targets in cancer
The identification of therapeutic strategies exploiting the metabolic alterations of malignant cells is a relevant area in cancer research. Here, we discuss a novel computational method, based on the COBRA (COnstraint-Based Reconstruction and Analysis) framework for metabolic networks, to perform th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-01-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1389672 |
| _version_ | 1827809477087199232 |
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| author | Iñigo Apaolaza Edurne San José-Eneriz Xabier Agirre Felipe Prósper Francisco J. Planes |
| author_facet | Iñigo Apaolaza Edurne San José-Eneriz Xabier Agirre Felipe Prósper Francisco J. Planes |
| author_sort | Iñigo Apaolaza |
| collection | DOAJ |
| description | The identification of therapeutic strategies exploiting the metabolic alterations of malignant cells is a relevant area in cancer research. Here, we discuss a novel computational method, based on the COBRA (COnstraint-Based Reconstruction and Analysis) framework for metabolic networks, to perform this task. Current and future steps are presented. |
| first_indexed | 2024-03-11T22:41:05Z |
| format | Article |
| id | doaj.art-b4dd61b803b243798ab063a1b88bbd2d |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:05Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-b4dd61b803b243798ab063a1b88bbd2d2023-09-22T09:10:59ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-01-015110.1080/23723556.2017.13896721389672COBRA methods and metabolic drug targets in cancerIñigo Apaolaza0Edurne San José-Eneriz1Xabier Agirre2Felipe Prósper3Francisco J. Planes4CEIT and Tecnun, University of Navarra, Manuel de Lardizábal 13University of NavarraUniversity of NavarraUniversity of NavarraCEIT and Tecnun, University of Navarra, Manuel de Lardizábal 13The identification of therapeutic strategies exploiting the metabolic alterations of malignant cells is a relevant area in cancer research. Here, we discuss a novel computational method, based on the COBRA (COnstraint-Based Reconstruction and Analysis) framework for metabolic networks, to perform this task. Current and future steps are presented.http://dx.doi.org/10.1080/23723556.2017.1389672cancerconstraint-based reconstruction and analysisdrug targetsessential genesgenetic minimal cut setsmetabolic networkspersonalized medicinesynthetic lethality |
| spellingShingle | Iñigo Apaolaza Edurne San José-Eneriz Xabier Agirre Felipe Prósper Francisco J. Planes COBRA methods and metabolic drug targets in cancer Molecular & Cellular Oncology cancer constraint-based reconstruction and analysis drug targets essential genes genetic minimal cut sets metabolic networks personalized medicine synthetic lethality |
| title | COBRA methods and metabolic drug targets in cancer |
| title_full | COBRA methods and metabolic drug targets in cancer |
| title_fullStr | COBRA methods and metabolic drug targets in cancer |
| title_full_unstemmed | COBRA methods and metabolic drug targets in cancer |
| title_short | COBRA methods and metabolic drug targets in cancer |
| title_sort | cobra methods and metabolic drug targets in cancer |
| topic | cancer constraint-based reconstruction and analysis drug targets essential genes genetic minimal cut sets metabolic networks personalized medicine synthetic lethality |
| url | http://dx.doi.org/10.1080/23723556.2017.1389672 |
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